1.河南中医药大学第一附属医院呼吸科,郑州 450000;2.河南中医药大学呼吸疾病中医药防治省部共建协同创新中心 河南省中医药防治呼吸病重点实验室,郑州 450046
R-33
SHI Yanglin
1. Respiratory Department of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000, China. 2. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China / Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Traditional Chinese Medicine, Zhengzhou 450046YANG Jianya
1. Respiratory Department of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000, China. 2. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China / Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Traditional Chinese Medicine, Zhengzhou 450046CHANG Qingqing
2. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China / Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Traditional Chinese Medicine, Zhengzhou 450046WANG Qianqian
2. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China / Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Traditional Chinese Medicine, Zhengzhou 450046WANG Minghang
1. Respiratory Department of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000, China. 2. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China / Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Traditional Chinese Medicine, Zhengzhou 450046LI Suyun
1. Respiratory Department of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000, China. 2. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China / Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Traditional Chinese Medicine, Zhengzhou 4500461. Respiratory Department of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000, China. 2. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China / Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Traditional Chinese Medicine, Zhengzhou 450046
脓毒症是由于宿主对感染的反应失调而导致的危及生命的器官功能障碍,死亡率极高,其是导致急性肺损伤(acute lung injury,ALI)的主要危险因素,然而脓毒症 ALI 的病理生理学和发病机制尚不完全清楚,有效药物极为有限。 因此,当务之急是挖掘脓毒症 ALI 的发病机制,并试图发现有效的干预措施,以改善脓毒症 ALI 患者的预后。 近年来,铁死亡被认为与脓毒症 ALI 的病理生理过程密切相关,抑制相关细胞铁死亡可有效延缓疾病的发生发展。本文对靶向相关细胞铁死亡的治疗策略进行综述,以期为脓毒症 ALI 铁死亡相关研究提供借鉴并为脓毒症 ALI 的治疗提供新的视角。
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection with an extremely high mortality rate, and it is the main risk factor for acute lung injury (ALI). However, the pathophysiology and pathogenesis of sepsis-associated ALI are not fully understood, and effective drugs are extremely limited. Therefore, it is urgent that we explore the pathogenesis of sepsis-associated ALI and attempt to discover effective intervention measures to improve the prognosis of sepsis-associated ALI patients. In recent years, ferroptosis has been considered closely related to the pathological and physiological processes of sepsis-associated ALI, and inhibiting related cell ferroptosis can effectively slow down the occurrence and development of the disease. In this paper, therapeutic strategies targeting ferroptosis in related cells are reviewed to provide a reference for future research on ferroptosis in sepsisassociated ALI and provide a new perspective on potential treatments.
史阳琳,杨建雅,常晴晴,王倩倩,王明航,李素云.铁死亡在脓毒症急性肺损伤中的研究进展[J].中国比较医学杂志,2024,34(6):130~134.
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