Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis of childhood, and is called “spot toxin”, “purpura wind”, and “ grape plague” in traditional Chinese medicine (TCM). Modern medical research suggests that the disease is related to factors such as an imbalance in cellular and humoral immunity, the abnormal secretion of cytokines, and disturbances to coagulation and fibrinolysis mechanisms, but the exact pathogenesis is still unclear. The incidence of this disease is increasing year by year, and it has a high recurrence rate and a high proportion of kidney damage, which seriously affects the physical and mental health of affected children and poses a great risk to human health. Numerous studies have shown the clinical efficacy of TCM treatment for HSP, but the mechanism of action is not completely clear. In recent years, following the establishment of animal models of HSP, a large number of animal experiments have been carried out to study the efficacy and mechanisms of TCM for HSP, but there is a lack of systematic and detailed reviews. Therefore, animal experimental literature related to the treatment of HSP with TCM in the past decade was reviewed. The effects of TCM in alleviating the abnormal glycosylation of IgA1, regulating the imbalances in Th1 / Th2 and Treg / Th17 immune cells, reducing circulating immune complexes, and inhibiting inflammatory responses were compiled and summarized to provide a reference for further research on TCM for the treatment of HSP and inspire new research ideas.