CAV1 在消化道肿瘤中的研究进展

doi:10.3969/j.issn.1671-7856.2024.07.013

首页 > 过刊浏览>2024年第34卷第7期 >110-120. DOI:10.3969/j.issn.1671-7856.2024.07.013

CAV1 在消化道肿瘤中的研究进展
DOI:
                        10.3969/j.issn.1671-7856.2024.07.013
                    
作者:
                        吴志航吴志航
甘肃中医药大学第一临床医学院,甘肃省中药新产品创制工程实验室,甘肃省中医方药挖掘与创新转化重点实验室,兰州 730000
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唐明政唐明政
甘肃中医药大学第一临床医学院,甘肃省中药新产品创制工程实验室,甘肃省中医方药挖掘与创新转化重点实验室,兰州 730000
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李晓凤李晓凤
甘肃中医药大学第一临床医学院,甘肃省中药新产品创制工程实验室,甘肃省中医方药挖掘与创新转化重点实验室,兰州 730000
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荣 耀荣 耀
甘肃中医药大学第一临床医学院,甘肃省中药新产品创制工程实验室,甘肃省中医方药挖掘与创新转化重点实验室,兰州 730000
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崔 岩崔 岩
甘肃中医药大学第一临床医学院,甘肃省中药新产品创制工程实验室,甘肃省中医方药挖掘与创新转化重点实验室,兰州 730000
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潘海邦潘海邦
甘肃中医药大学第一临床医学院,甘肃省中药新产品创制工程实验室,甘肃省中医方药挖掘与创新转化重点实验室,兰州 730000
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作者单位:甘肃中医药大学第一临床医学院,甘肃省中药新产品创制工程实验室,甘肃省中医方药挖掘与创新转化重点实验室,兰州 730000
作者简介:
通讯作者:
中图分类号:R-33
基金项目:

Advances in the study of CAV1 in digestive tract tumors

Author:

WU Zhihang
WU Zhihang
the First College of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Gansu Provincial Engineering Laboratory for the Creation of New Traditional Chinese Medicine Products, Gansu Provincial Key Laboratory of Chinese Medicine Formulas Excavation and Innovative Transformation, Lanzhou 730000, China
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TANG Mingzheng
TANG Mingzheng
the First College of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Gansu Provincial Engineering Laboratory for the Creation of New Traditional Chinese Medicine Products, Gansu Provincial Key Laboratory of Chinese Medicine Formulas Excavation and Innovative Transformation, Lanzhou 730000, China
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LI Xiaofeng
LI Xiaofeng
the First College of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Gansu Provincial Engineering Laboratory for the Creation of New Traditional Chinese Medicine Products, Gansu Provincial Key Laboratory of Chinese Medicine Formulas Excavation and Innovative Transformation, Lanzhou 730000, China
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RONG Yao
RONG Yao
the First College of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Gansu Provincial Engineering Laboratory for the Creation of New Traditional Chinese Medicine Products, Gansu Provincial Key Laboratory of Chinese Medicine Formulas Excavation and Innovative Transformation, Lanzhou 730000, China
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CUI Yan
CUI Yan
the First College of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Gansu Provincial Engineering Laboratory for the Creation of New Traditional Chinese Medicine Products, Gansu Provincial Key Laboratory of Chinese Medicine Formulas Excavation and Innovative Transformation, Lanzhou 730000, China
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PAN Haibang
PAN Haibang
the First College of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Gansu Provincial Engineering Laboratory for the Creation of New Traditional Chinese Medicine Products, Gansu Provincial Key Laboratory of Chinese Medicine Formulas Excavation and Innovative Transformation, Lanzhou 730000, China
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Affiliation:

the First College of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Gansu Provincial Engineering Laboratory for the Creation of New Traditional Chinese Medicine Products, Gansu Provincial Key Laboratory of Chinese Medicine Formulas Excavation and Innovative Transformation, Lanzhou 730000, China

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摘要:

消化道肿瘤是目前全球最常见的癌症之一,包括食管癌、胃癌、肝癌、胰腺癌和结直肠癌等,其预后不佳,治疗方法仍需进一步改进。小窝蛋白-1(caveolin-1,CAV1)在消化道肿瘤中具有双重调节作用,既是肿瘤抑制因子又是致癌因子。 CAV1 对消化道肿瘤的细胞增殖、侵袭、转移、血管生成和药物耐受性等方面具有重要作用,调节 CAV1 蛋白及其相关信号通路可能成为治疗消化道肿瘤的策略之一。因此,本综述就 CAV1 的结构、功能、表达调控以及调节消化道肿瘤上皮-间充质转换( epithelial-mesenchymal transition,EMT) 及其耐药性等方面分析CAV1 与消化道肿瘤的关系,以期为临床消化道肿瘤的诊疗提供新的思路。

关键词:CAV1;消化道肿瘤;EMT;耐药

Abstract:

Digestive tract tumors are currently one of the most common types of cancer, including esophageal cancer, gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. Their prognoses are poor and the treatments require further improvement. Caveolin-1 (CAV1) has a dual regulatory effect on digestive tract tumors as a tumor suppressor and cancer promoter. CAV1 plays a major role in cell proliferation, invasion, metastasis, angiogenesis,and drug tolerance of digestive tract tumors. The regulation of CAV1 protein and its related signaling pathways may be a strategy for the treatment of digestive tract tumors. This review analyzes the relationship between CAV1 and digestive tract tumors in terms of structure, function, expression regulation, regulation of epithelial-mesenchymal transition, and drug resistance in digestive tract tumors to provide new ideas for the diagnosis and treatment of digestive tract tumors.

Key words:CAV1; digestive tract tumor; EMT; drug resistance

引用本文

吴志航,唐明政,李晓凤,荣耀,崔岩,潘海邦. CAV1 在消化道肿瘤中的研究进展[J].中国比较医学杂志,2024,34(7):110~120.

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收稿日期:2023-07-13
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在线发布日期: 2024-08-19
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