Ankylosing spondylitis is an autoimmune disease with sacroiliac arthritis and spinal arthritis as the main manifestations. The disease mainly occurs in young men, has a high disability rate, and is a serious threat to the life and health of patients. Biological agents are expensive, and many adverse reactions to hormones, non-steroidal antiinflammatory drugs, and anti-rheumatic drugs have been recorded. Traditional Chinese medicine can regulate the immunity and anti-inflammatory effects of the disease, and has good clinical effects. To promote the further study of the pathogenesis of ankylosing spondylitis and the development and screening of therapeutic drugs and therapies, in this paper, we summarize the method and mechanisms of modeling of the existing animal model of ankylosing spondylitis and analyze the advantages and disadvantages of the model. To evaluate the agreements between Chinese and Western medicine clinical characteristics, we compare the characteristics of Chinese and Western medical syndromes of the animal model. Building an animal model of ankylosing spondylitis with a higher degree of consistency between traditional Chinese and Western medicine is the key to innovative research into traditional Chinese medicine method of treating ankylosing spondylitis. To lay the foundation for research into traditional Chinese medicines and acupuncture for ankylosing spondylitis, this paper analyzes the degree of concurrence between the Chinese and Western medicine clinical characteristics of animal models.