基于调控AMPK信号通路的中药治疗脑缺血再灌注损伤药理机制研究进展

doi:10.3969/j.issn.1671-7856.2024.09.015

首页 > 过刊浏览>2024年第34卷第9期 >127-136. DOI:10.3969/j.issn.1671-7856.2024.09.015

基于调控AMPK信号通路的中药治疗脑缺血再灌注损伤药理机制研究进展
DOI:
                        10.3969/j.issn.1671-7856.2024.09.015
                    
作者:
                        贺晨菲1,2贺晨菲
1.河南中医药大学第一附属医院脑病中心,郑州 450000;2.河南中医药大学第一临床医学院,郑州 450046
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马驰远1马驰远
1.河南中医药大学第一附属医院脑病中心,郑州 450000
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冉春龙1冉春龙
1.河南中医药大学第一附属医院脑病中心,郑州 450000
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程豪格1,2程豪格
1.河南中医药大学第一附属医院脑病中心,郑州 450000;2.河南中医药大学第一临床医学院,郑州 450046
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张 数1,2张 数
1.河南中医药大学第一附属医院脑病中心,郑州 450000;2.河南中医药大学第一临床医学院,郑州 450046
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王森雨1,2王森雨
1.河南中医药大学第一附属医院脑病中心,郑州 450000;2.河南中医药大学第一临床医学院,郑州 450046
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宇翰林1,2宇翰林
1.河南中医药大学第一附属医院脑病中心,郑州 450000;2.河南中医药大学第一临床医学院,郑州 450046
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刘向哲1刘向哲
1.河南中医药大学第一附属医院脑病中心,郑州 450000
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作者单位:1.河南中医药大学第一附属医院脑病中心,郑州 450000;2.河南中医药大学第一临床医学院,郑州 450046
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中图分类号:R-33
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Research progress on the AMPK signaling pathway-based pharmacological mechanism of traditional Chinese medicine in the treatment of cerebral ischemia-reperfusion injury

Author:

HE Chenfei ^{^1,2}
HE Chenfei
1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China. 2. Henan University of Traditional Chinese Medicine First Clinical Medical College, Zhengzhou 450046
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MA Chiyuan ^¹
MA Chiyuan
1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
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RAN Chunlong ^¹
RAN Chunlong
1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
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CHENG Haoge ^{^1,2}
CHENG Haoge
1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China. 2. Henan University of Traditional Chinese Medicine First Clinical Medical College, Zhengzhou 450046
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ZHANG Shu ^{^1,2}
ZHANG Shu
1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China. 2. Henan University of Traditional Chinese Medicine First Clinical Medical College, Zhengzhou 450046
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WANG Senyu ^{^1,2}
WANG Senyu
1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China. 2. Henan University of Traditional Chinese Medicine First Clinical Medical College, Zhengzhou 450046
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YU Hanlin ^{^1,2}
YU Hanlin
1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China. 2. Henan University of Traditional Chinese Medicine First Clinical Medical College, Zhengzhou 450046
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LIU Xiangzhe ^¹
LIU Xiangzhe
1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
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Affiliation:

1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China. 2. Henan University of Traditional Chinese Medicine First Clinical Medical College, Zhengzhou 450046

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摘要:

脑缺血再灌注损伤(cerebral ischemia-reperfusion injury, CIRI)指脑血管缺血后血液再次恢复供应,导致脑组织进一步的损伤和功能障碍。目前,现代医学在CIRI的防治中取得了一定的进展,但仍然面临一些挑战和局限性。因此,寻找有效的干预措施来防治CIRI具有重要的临床价值。腺苷酸活化蛋白激酶(AMPK)及其下游蛋白是治疗CIRI的重要靶点,在细胞能量稳态调节中起着关键作用。中药具有多靶点、多途径和多效应的特点,可以激活AMPK信号通路级联反应,通过调节细胞自噬、氧化应激、炎症反应、细胞凋亡等来治疗CIRI,并取得一定成果。故文章总结了AMPK相关信号通路的结构与机制,详述其与CIRI的关系,并对中医药调控AMPK信号通路防治CIRI的研究现状进行系统性总结,以期为CIRI的中医防治及新药研发提供新的思路。

关键词:中药;AMPK信号通路;脑缺血再灌注损伤;研究进展

Abstract:

Cerebral ischemia-reperfusion injury (CIRI) refers to the recovery of blood supply after cerebral ischemia, which leads to further damage and the dysfunction of brain tissue. Modern medicine has made some progress in the prevention and treatment of CIRI, but it still faces some challenges and limitations. Therefore, it is of great clinical value to find effective interventions to prevent and treat CIRI. AMP-activated protein kinase (AMPK) and its downstream proteins are important targets for the treatment of CIRI and play key roles in the regulation of cellular energy homeostasis. Traditional Chinese medicine for CIRI has multi-target and multi-pathway activities and multiple effects. It can activate a cascade of reactions in the AMPK signaling pathway and can be used to treat CIRI by regulating autophagy, oxidative stress, inflammatory response, and apoptosis, and has achieved certain result. Therefore, this paper summarizes the structure and mechanisms of the AMPK-related signaling pathway, elaborates on its relationship with CIRI, and systematically summarizes the research status of traditional Chinese medicine’s ability to regulate the AMPK signaling pathway in the prevention and treatment of CIRI. This paper aims to provide new ideas for the prevention and treatment of CIRI using traditional Chinese medicine and the development of new drugs.

Key words:traditional Chinese medicine; AMPK signaling pathway; cerebral ischemia-reperfusion injury; research progress

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贺晨菲,马驰远,冉春龙,程豪格,张数,王森雨,宇翰林,刘向哲.基于调控AMPK信号通路的中药治疗脑缺血再灌注损伤药理机制研究进展[J].中国比较医学杂志,2024,34(9):127~136.

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收稿日期:2024-03-08
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在线发布日期: 2024-10-30
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