Continuing global research into and the development of hemoglobin-based oxygen carriers (HBOC) has led to increasing attention on ways by which to evaluate their performance in the circulation. This article reviews the preparation method , observation indicators, performance evaluation, and selection suggestions of the main HBOC circulatory performance-evaluation models, including the hemorrhagic shock, isovolumetric blood exchange,circulatory top load, and ischemia-reperfusion models, together with the development of other biomimetic models.