Parkinson’s disease (PD) is a common progressive neurodegenerative disease mainly affecting the motor system. Various genetic factors and cellular mechanisms underlying PD have recently been discovered. Emerging evidence suggests that epigenetic modifications play a very important role in the pathogenesis, prevention, and treatment of PD. Epigenetic modification mediates genetic and environmental interactions mainly through complex interactions of DNA methylation, histone modification, and non-coding RNA, thereby affecting expression in the absence of changes in DNA sequence. In this review, we summarize the epigenetic modification mechanisms involved in the pathogenesis of Parkinson’s disease. In this review, we summarize the epigenetic modification mechanisms involved in the pathogenesis of Parkinson’s disease.Recent studies have found that traditional Chinese medicine can participate in the regulation of abnormal epigenetic modifications in the treatment of PD. Traditional Chinese medicine benefits from its multi-level and multi-target regulatory effects, and various traditional Chinese medicine monomers, compound prescriptions, and techniques have been evaluated, confirming that this is a promising approach for improving symptoms in PD. This review summarizes the mechanisms by which epigenetic modifications contribute to PD, explores the role of traditional Chinese medicine, and provides new ideas for clinical treatment and drug development in PD through epigenetic intervention.