Myocardial infarction is a cardiovascular disease with high rates of fatality. New targets are needed for the development of novel therapeutics that can protect heart function and prevent heart failure. Triggering receptor expressed myeloid cell ( TREM ) is an activating transmembrane receptor belonging to the immunoglobulin superfamily. TREM-1 and TREM-2 are the most important TREM family members, and are predominantly expressed on the surface of myeloid cells. TREM-1 and TREM-2 have similar transmembrane glycostructures, but they play different roles in regulating inflammatory responses. TREM play an important role in the inflammatory response,myocardial remodeling, and myocardial cell regeneration after myocardial infarction. This review summarizes the functions, expression patterns, and ligand combinations of TREM-1 and TREM-2, and discusses the roles of their signaling pathways in myocardial infarction. New targets for the treatment of myocardial infarction are proposed.