Drug addiction is a serious public health problem worldwide, for which there are currently no established therapeutic medications. Since the legalization of cannabis and the approval of cannabidiol (CBD) by the US Food and Drug Administration, its therapeutic potential for the treatment of substance abuse has been widely explored. Numerous studies have shown that CBD can reduce drug reward in animal models of addiction such as selfadministration, conditioned positional preference, and intracranial self-stimulation. CBD can also reduce withdrawal symptoms from substances such as amphetamines, opioids, cocaine, marijuana, alcohol, and nicotine. The mechanisms by which CBD modulates drug addiction, however, are complex and understudied. Here we review studies of CBD related to addictive drugs to clarify the regulatory mechanisms of CBD in drug addiction and provide references for related studies on substance abuse.