Sj?gren’ s syndrome ( SS) is a chronic autoimmune disease with a complex pathogenesis. In addition to lymphocyte infiltration and inflammatory damage of the glands, it often involves multiple systems.However, treatment options are limited. Studies have found that mitochondrial quality control dysfunction is closely related to inflammation in autoimmune diseases. This article evaluates the correlation between mitochondrial quality control dysfunction and glandular damage in SS, aimed at broadening the horizons for the treatment of SS.