行为学实验新型刺激装置的设计与应用
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1.山东大学齐鲁医学院基础医学院,济南 250012;2.郑州大学医科院,郑州 450052;3.成都泰盟软件有限公司,成都 610101

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B841. 4

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Design and implementation of a novel behavioral experiment stimulation device
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1. School of Basic Medical Sciences, College of Medicine, Shandong University, Jinan 250012, China.2. Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052.3. Chengdu Taimeng Software Company Limited, Chengdu 610101

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    摘要:

    目的 针对传统行为学实验装置的缺陷,设计一种智能化、集成化、精准化的行为学实验新型刺激装置,用于心理学实验项目“肾上腺素受体激动剂对习得性焦虑的易化作用”。 方法 行为学实验新型刺激装置集电/ 声刺激、可视观察、恒温控制及计算机操控于一体,核心组件包括操控系统、主微处理器、供电系统、电刺激器、噪声刺激器、恒温控制及可视观察箱,通过声音的条件刺激结合足部电击的非条件刺激诱发大鼠产生焦虑。 结果 解决了分散操作的弊端,实现了电刺激与噪声刺激的精确同步,确保了条件-非条件刺激的严格关联,可预设刺激序列使实验流程程序化,降低了人为操作失误的风险,实验可重复性显著提高,加深了学生对焦虑行为的科学认知,还可用于疼痛研究及其他行为学实验。 结论 行为学实验新型刺激装置一机多能,是传统医学专业课程以教学需求为导向,医工结合,推进课程建设,助力人才培养的有效探索。

    Abstract:

    Objective To address limitations of conventional behavioral experimental apparatuse and to design an intelligent, integrated, and precise novel stimulation device for psychology experiments to investigate the facilitative effects of adrenoceptor agonists on learned anxiety. Methods We developed an integrated behavioral experiment stimulation device combining electrical / acoustic stimulation, visual observation, thermostatic control, and computerized operation. The core components included a control system, main microprocessor, power supply, electrical stimulator, noise stimulator, thermostatic unit, and visual observation chamber. We used the device to deliver conditioned auditory stimuli paired with unconditioned foot-shock stimuli to induce anxiety in rats. Results The device eliminated the drawbacks of fragmented operations and achieved precise synchronization of electrical and noise stimuli, ensured strict correlation between conditioned and unconditioned stimuli, and enabled programmable preset stimulation sequences. The device accordingly reduced the risk of operational error, significantly improved experimental repeatability, and increased students’ scientific understanding of anxiety behaviors. The device also demonstrated applicability to pain research and other behavioral experiments. Conclusions As a multifunctional instrument, this novel device represents a valuable addition to the traditional medical curriculum, by addressing teaching-oriented demands through medicine-engineering integration, advancing course development, and enhancing talent cultivation.

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张 斌,马韫韬,赖 勇,马 湉,吴继超,马剑峰,江 虹.行为学实验新型刺激装置的设计与应用[J].中国比较医学杂志,2026,36(1):71~79.

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  • 收稿日期:2025-07-18
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  • 在线发布日期: 2026-02-10
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