The global incidence of autism spectrum disorder ( ASD) shows a significant upward trend.Analysis of its pathological mechanism and development of intervention strategies are major challenges in the field of neurodevelopmental disorders. Exercise intervention can significantly alleviate social disorders, cognitive deficits, and stereotyped behaviors in individuals with ASD, but the neurobiological mechanisms of these effects need to be systematically elucidated. The striatum has a pivotal role in the cortical basal ganglia loop and is closely associated with ASD behavior and functional abnormalities and this review focuses on the key role of striatal remodeling in exercise intervention. Integration of evidence from animal experiments and clinical research has shown the striatum to be involved in exercise-mediated improvement in autism behavior. These observations include strengthening the morphological structure of striatal regions, improving the expression of striatal neurotrophic factors, regulating the transmission of dopamine signals in striatal regions, and enhancing the transmission of cortico-striatal glutamatergic signals. By exploring the potential role of the striatum in improving autism behavior through exercise, this multi-scale analysis framework aims to elucidate the potential role of “striatal motor remodeling for ASD behavior improvement”and to provide new ideas for exercise-based improvement of autism behavior.