Guangxi Science and Technology Infrastructure construction project (10-108-19)
糖尿病是一种内分泌代谢性疾病，主要有1型糖尿病和2型糖尿病，其中患者绝大部分为2型糖尿病，且病程缓慢，并常伴有不同程度的心脑血管、肾、视网膜、以及神经病变等并发症。糖尿病并发症的发生率、致残率和致死率都相当高，为其治疗带来了巨大的挑战。目前，国内外在2型糖尿病并发症动物模型方面进行了研究与探讨，主要通过注射链脲佐菌素（STZ）诱导大鼠2型糖尿病并发症，该造模方法能较好的模拟出类似人类2型糖尿病并发症病变特征，为2型糖尿病的预防与治疗提供了一定的参考价值
Diabetes is a kind of endocrine metabolic disease, which mainly including type 1 diabetes and type 2 diabetes, most of them are the latter, with low course and different degrees of complications. The incidence rate, disability rate and fatality rate of diabetes are quite high, which bring a big challenge for the treatment. For now, there are many researches and discussions in animal models of type 2 diabetes complications at home and abroad, mainly through the injection of STZ to induce type 2 diabetes complications, which can show the lesion characteristics better, all of these study can provide some references for the prevention and curing of type 2 diabetes.
陈永欣.链脲佐菌素诱导大鼠2型糖尿病并发症模型研究进展[J].中国比较医学杂志,2013,23(3).
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