Key Laboratory of Pharmacology of Dongzhimen Hospital (Beijing University of Chinese Medicine), State Administration of Traditional Chinese Medicine 在期刊界中查找 在百度中查找 在本站中查找
Key Laboratory of Pharmacology of Dongzhimen Hospital (Beijing University of Chinese Medicine), State Administration of Traditional Chinese Medicine 在期刊界中查找 在百度中查找 在本站中查找
Key Laboratory of Pharmacology of Dongzhimen Hospital (Beijing University of Chinese Medicine), State Administration of Traditional Chinese Medicine 在期刊界中查找 在百度中查找 在本站中查找
Key Laboratory of Pharmacology of Dongzhimen Hospital (Beijing University of Chinese Medicine), State Administration of Traditional Chinese Medicine 在期刊界中查找 在百度中查找 在本站中查找
Key Laboratory of Pharmacology of Dongzhimen Hospital (Beijing University of Chinese Medicine), State Administration of Traditional Chinese Medicine 在期刊界中查找 在百度中查找 在本站中查找
Key Laboratory of Pharmacology of Dongzhimen Hospital (Beijing University of Chinese Medicine), State Administration of Traditional Chinese Medicine 在期刊界中查找 在百度中查找 在本站中查找
Key Laboratory of Pharmacology of Dongzhimen Hospital (Beijing University of Chinese Medicine), State Administration of Traditional Chinese Medicine 在期刊界中查找 在百度中查找 在本站中查找
Key Laboratory of Pharmacology of Dongzhimen Hospital (Beijing University of Chinese Medicine), State Administration of Traditional Chinese Medicine 在期刊界中查找 在百度中查找 在本站中查找
Objective Using Morris water maze to evaluate the effect of curcumin on cognitive function of APPswe/PS1dE9 double transgenic mice. Methods 3-month old APPswe/PS1dE9 dtg mice were randomly divided into model group, Rosiglitazone group and curcumin large, medium and small dose group( n=6), with age-matched C57BL/6J mice of the same genetic background as normal control group. Medication was given once a day by intragastric administration for 6 months. Application of Morris water maze to test APPswe/PS1dE9 double transgenic mice spatial learning and memory ability. Results Curcumin to APPswe/PS1dE9 double transgenic mice spatial learning and memory disabilities have improvement effect, especially in curcumin-M dose group in the more obvious effects. Conclusion Curcumin can improve learning and memory ability of APPswe/PS1dE9 double transgenic mice.