姜黄素对9月龄APPswe/PS1dE9双转基因小鼠行为学的影响
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国家自然基金面上资助项目(No. 81073076),教育部高等学校创新团队(IRT0810)


The effect of curcumin on the ethology in APPswe/PS1dE9 transgenic mice
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    摘要:

    目的 应用Morris水迷宫,测试AD模型APPswe/PS1dE9双转基因小鼠定位航行及空间搜索等学习记忆和记忆保持能力,评价姜黄素对APPswe/PS1dE9双转基因小鼠认知功能的影响。方法 将3月龄的APPswe/PS1dE9双转基因小鼠随机分为模型组、罗格列酮组(10 mg?kg-1?d-1)、姜黄素高(400 mg?kg-1?d-1)、中(200 mg?kg-1?d-1)、低剂量组(100 mg?kg-1?d-1),每组6只;并以同月龄遗传背景相同的C57/BL6J小鼠作为对照组。每天灌胃给药1次,连续灌胃6个月。应用Morris水迷宫进行行为学检测。结果 姜黄素对APPswe/PS1dE9双转基因小鼠空间学习记忆能力障碍有改善作用,尤以姜黄素中剂量组效果比较明显。结论 姜黄素能改善APPswe/PS1dE9双转基因小鼠的认知功能。

    Abstract:

    Objective Using Morris water maze to evaluate the effect of curcumin on cognitive function of APPswe/PS1dE9 double transgenic mice. Methods 3-month old APPswe/PS1dE9 dtg mice were randomly divided into model group, Rosiglitazone group and curcumin large, medium and small dose group( n=6), with age-matched C57BL/6J mice of the same genetic background as normal control group. Medication was given once a day by intragastric administration for 6 months. Application of Morris water maze to test APPswe/PS1dE9 double transgenic mice spatial learning and memory ability. Results Curcumin to APPswe/PS1dE9 double transgenic mice spatial learning and memory disabilities have improvement effect, especially in curcumin-M dose group in the more obvious effects. Conclusion Curcumin can improve learning and memory ability of APPswe/PS1dE9 double transgenic mice.

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樊惠,魏鹏,陈晓培,冯慧利,任映,孙海芸,杨金铎,王蓬文.姜黄素对9月龄APPswe/PS1dE9双转基因小鼠行为学的影响[J].中国比较医学杂志,2013,23(6).

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  • 收稿日期:2013-04-01
  • 最后修改日期:2013-04-19
  • 录用日期:2013-05-13
  • 在线发布日期: 2013-07-02
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