Objective To observe myocardial infarction area, cardiac troponin -T (cTn-T) expression, expression of Bax, Bcl-2 mRNA of blueberry anthocyanins (Blueberry anthocyanin BBA) pretreatment on experimental acute myocardial infarction in rats and explore the intervention of the mechanism of myocardial infarction. Methods 40 Wistar rats were randomly divided into sham operation group, myocardial infarction model group, BBA low, middle, high dose group, drug intervention for 4 weeks, after 30 minutes of the last administration, ligate branch ligation of the left anterior descending coronary artery to establish myocardial infarction animal model. After 24 hours, TTC detection of myocardial infarction area; Western blotting detection of myocardial cells cTn-T protein expressing; expression of real time PCR for detection of Bcl-2 mRNA, Bax mRNA. Conclusion Protective effect of blueberry anthocyanins on myocardial cells after myocardial infarction is clear, its mechanism may be related to reduce the area of myocardial infarction; up-regulate the expression of cTn-T protein, up-regulate the Bcl-2 mRNA expression, down-regulate the Bax mRNA expression, inhibite myocardial cell apoptosis after myocardial infarction.