基于SYRCLE工具与ARRIVE指南评价针刺干预高血压动物实验研究的质量
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作者单位:

1.成都中医药大学养生康复学院;2.成都中医药大学;3.天津中医药大学第一附属医院

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基金项目:

国家自然科学基金项目(面上项目,重点项目,重大项目);四川省科技创新人才项目;国家中医药管理局中医药养生健康产业发展重点研究室、四川省中医药养生健康重点实验室开放课题


The evaluation of experimental animal studies on acupuncture for hypertension based on the SYRCLE’s tool and the ARRIVE guidelines
Author:
Affiliation:

1.Chengdu University of Traditional Chinese Medicine;2.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    目的 评价针刺干预高血压动物实验研究的偏倚风险与报告质量,分析实验设计、实施与报告中存在的不足,以减少动物实验偏倚风险和提高报告质量。方法 计算机检索中国知网、万方、维普、中国生物医学文献数据库、Web of science、PubMed、Embase、The Cochrane Library等数据库,限制时间为建库至2022年10月8日,由两名研究员根据合格标准独立筛选针刺干预高血压动物的相关实验研究,并使用SYRCLE工具与ARRIVE指南2.0对纳入文献进行偏倚风险与报告质量评价。运用Excel 2019提取数据,根据结果进行描述性分析。结果 共纳入79篇针刺干预高血压的动物实验文献,其中有16篇文献与21篇文献分别发表在中文核心期刊和SCI期刊上。SYRCLE评价工具显示,10个条目中有5个条目评估良好,其他条目均存在描述不充分或偏倚风险高的问题。在纳入的79篇文献中,19篇文献的偏倚风险较低,其余研究均存在一定的偏倚风险。ARRIVE指南2.0评价结果显示,38个亚条目中,有19个条目报告良好,而其他条目报告情况均较差。51篇文献的报告质量良好,其余研究报告不充分。结论 目前,针刺干预高血压动物实验的偏倚风险较高,报告质量普遍偏低。由于多数重要条目描述不充分,导致实验可重复性和结果转化均受到影响。建议在实验设计和报告过程中参考SYRCLE工具与ARRIVE指南2.0,以提高针刺干预高血压动物实验的规范性与整体质量。

    Abstract:

    Objective To evaluate the risk of bias and reporting quality of animal experimental studies on acupuncture for hypertension, and analyze the deficiencies in experimental design, implementation and reporting, so as to decrease the risk of bias of researches and improve the reporting quality of animal studies. Methods Databases including China national knowledge infrastructure(CNKI), Wanfang database(WANFANG), Chinese science and technology periodical database(VIP), Chinese biomedical literature database(CBM), Web of Science, PubMed, Embase, and The Cochrane Library were searched from inception to October 8, 2022. Two researchers independently screened experimental studies related to acupuncture interventions in hypertensive animals according to eligibility criteria. The SYRCLE’s tool and the ARRIVE guidelines 2.0 were used to evaluate the risk of bias and reporting quality of the included literature. Excel 2019 was used to extract data and descriptive analysis was conducted according to the results. Results A total of 79 animal experiments on acupuncture for hypertension were included, among which 16 and 21 were published in Chinese core journals and science citation index(SCI)journals respectively. The result of SYRCLE’s tool showed that 5 of the 10 items were evaluated as well, while the rest were unclear risk or high risk of bias. Of the 79 included articles, the risk of bias of 19 articles were low, while the remaining studies had some risk of bias. The results of the ARRIVE guidelines 2.0 indicated that 19 of the 38 sub-items were well reported, while the rest were poorly reported.The reporting quality of 51 articles were good and the remaining studies were inadequately reported. Conclusions At present, the risk of bias of acupuncture intervention in hypertensive animal experiments is high and the reporting quality is generally low. The inadequate description of some important entries had impact on the reproducibility of the experiments and the translation of the results.The SYRCLE’s tool and ARRIVE guidelines 2.0 are recommended to be used as reference during experimental design and reporting, thus improving the standardization and reporting quality of acupuncture for hypertensive animals.

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  • 收稿日期:2022-10-18
  • 最后修改日期:2022-12-30
  • 录用日期:2023-09-05
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