非人灵长类帕金森动物模型中的行为学评估
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1.昆明理工大学非人灵长类转化医学院;2.昆明理工大学灵长类转化医学研究院

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国家自然科学基金;云南省科技厅人才项目


Behavioral assessment in the parkinson’s model of nonhuman primates
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1.KUST;2.Institute of Primate Translational Medicine,Kunming University of Science and Technology

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    摘要:

    帕金森病(Parkinson's disease,PD)是一种神经退行性疾病,目前发病机制不明,病人会出现与疾病相关的运动和非运动症状。啮齿类动物模型只能部分精准模拟病人的症状,导致相关的临床前研究存在局限性,非人灵长类动物模型能够较好的弥补这种缺陷,对非人灵长类PD模型的运动和非运动症状的量化有利于发病机制和治疗的研究,本综述中总结了不同行为学量化方式,同时对比了不同方法之间的优劣性,为进行PD猴模型研究提供了行为学测试的参考。

    Abstract:

    Parkinson's disease is a neurodegenerative disease, can cause a series of patients with symptoms of movement and the movement, behind the pathogenesis is unclear, to explore the mechanism behind these phenotypic requires an appropriate animal model of rodents in the movement and the movement is very difficult to accurately simulate the patient symptoms, causes related to preclinical studies have limitations, in translational medicine. Non-human primate animal models can make up the gap between rodents and humans, thus the non-human primate PD model of movement and the movement symptoms, is very important to research on mechanism and therapy, this review summarizes the different behavior in quantitative way, and compared the advantages and disadvantages between different methods, for studying the PD monkey model provides a behavioral testing for help.

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  • 收稿日期:2022-12-21
  • 最后修改日期:2023-06-25
  • 录用日期:2023-09-05
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