Abstract: Vascular Dementia (VD) is caused by cerebrovascular diseases, either hemorrhage or ischemic damage in the brain, with ischemia being the most common. In recent years, much more efforts have been made to study the etiology, pathogenesis and prevention of VD. The establishment of appropriate animal models for studying the mechanism of VD and exploring efficacy of VD treatment has become one of key issues in the research field. On the basis of the conventional methods such as the bilateral occlusion of the common carotid arteries (2VO) and the four-vessel occlusion, the researchers had modified these methods to improve the stability with better reflection of the clinical manifestations of VD. This paper mainly summaries these modified methods, and discuss possible cellular and molecular mechanisms and their advantages and disadvantages.