Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality, which has become an important health problem in today's society. Traditionray Chinese Medicine has accumulated rich historical experience in the treatment of COPD and has unique clinical advantages. In order to further explore the therapeutic effect of traditional Chinese medicine on this disease, the preparation of COPD animal model combining disease and syndrome is the key premise of studying the occurrence and development of the disease. The combined models of disease and syndrome summarized in this paper include five types: the animal model of lung qi deficiency, the animal model of lung and spleen deficiency, the animal model of phlegm-heat stagnation of lung, the animal model of phlegm-stasis obstructing lung, and the animal model of cold drink. Now the common disease and syndrome in recent years combined with the method of class modeling are simply described and combed, in order to provide new ideas for researchers, and promote the research process of traditional Chinese medicine treatment of this disease.