Methamphetamine (METH) is highly addictive and neurotoxic, which can cause cognitive and memory dysfunction in abusers. The harm of METH lies not only in its own toxicity, but also in the high physical and mental dependence of drug addicts, often causing mental disorders and causing violent behavior, bringing great safety risks to society. Non-coding RNA (ncRNA) does not code for proteins and is an important factor in regulating gene expression at the post-transcriptional level. Studies have shown that ncRNA plays an important regulatory role in methamphetamine-induced addiction and neurotoxicity, but the specific mechanism is unclear. This article reviews the current research progress of ncRNA in regulating METH-induced addiction and neurotoxicity, in order to provide a reference for ncRNA as a forensic identification index and potential drug intervention target for METH abusers.