Ankylosing spondylitis is an autoimmune disease with sacroiliac arthritis and spinal arthritis as the main manifestations. The disease mainly occurs in young men, with a high disability rate and a serious threat to the life and health of patients. Biological agents are expensive, and there are many adverse reactions of hormones, non-steroidal anti-inflammatory drugs and anti-rheumatic drugs. Traditional Chinese medicine can regulate immunity and anti-inflammatory, and has a good clinical effect. In order to further study the pathogenesis of ankylosing spondylitis and the development and screening of therapeutic drugs, this paper summarizes the modeling method and mechanism of the existing animal model of ankylosing spondylitis, and analyse advantages and disadvantages of the model. To evaluate the coincidence of Clinical Characteristics of Chinese Medicine and Western Medicine,the paper compares the characteristics of Chinese and Western medical syndromes of the animal model. To build an animal model of ankylosing spondylitis with a higher degree of coincidence between traditional Chinese and western medicine is the key to innovative research of traditional Chinese medicine for treating ankylosing spondylitis. In order to lay a foundation for the research of traditional Chinese medicine for ankylosing spondylitis，this paper analyzes the degree of coincidence between Clinical Characteristics of Chinese Medicine and Western Medicine of animal model.