Laser speckle contrast imaging technology can be used to dynamically measure microcirculation blood flow in tissues or organs in a visual and quantifiable way. Because of its advantages of in vivo detection, real-time imaging and simple operation, it has been applied in many fields of microcirculation detection.The animal model of chronic cerebral hypoperfusion is mainly constructed by reducing the bilateral common carotid artery blood flow to the brain, which can cause long-term insufficient cerebral blood supply. Laser speckle contrast imaging technology can observe and analyze the cortical cerebral blood flow, collateral circulation opening, neurovascular coupling response, etc., in the animal model of chronic cerebral hypoperfusion , so as to judge the success of animal model modeling and the therapeutic effect of intervention methods. In this paper, the application and advantages and disadvantages of laser speckle contrast imaging technology in the animal model of chronic cerebral hypoperfusion were summarized in order to provide new ideas for clinical treatment and scientific research.