程序性细胞死亡在脑卒中后认知障碍中的研究进展
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1.河南中医药大学;2.河南中医药大学第一附属医院

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Advances of Programmed Cell Death in Post-stroke Cognitive Impairment
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1.Henan University of Chinese Medicine;2.the First Affiliated Hospital of Henan University of CM

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    摘要:

    脑卒中后认知障碍(PSCI)是脑卒中后常见并发症之一,对卒中患者的生活质量影响较大,但发病机制尚未能完全解释清楚。越来越多的证据表明,程序性细胞死亡(PCD)机制与PSCI有关,包括细胞凋亡、坏死性凋亡、细胞焦亡、泛凋亡、PARP-1依赖性细胞死亡和铁死亡等。因此,清楚了解各种PCD机制及其与PSCI的关系,阐明PCD在疾病发病机制中的作用至关重要。文章综述了与PSCI相关的6种PCD途径,总结其在PSCI中的作用机制,并阐述了不同途径之间可能存在的串扰,以期为临床靶向PCD途径的调节因子来治疗PSCI提供资料依据。

    Abstract:

    Post-stroke cognitive impairment (PSCI) is one of the common complications after stroke, which has a significant impact on the quality of life of stroke patients. However, the pathogenesis has not been fully explained. More and more evidence shows that the mechanism of programmed cell death (PCD) is related to PSCI, including apoptosis, necrotic apoptosis, pyroptosis, generalized apoptosis, PARP-1 dependent cell death and iron death. Therefore, it is crucial to have a clear understanding of various mechanisms of PCD and their relationship with PSCI, and to elucidate the role of PCD in the pathogenesis of diseases. The article reviews six PCD pathways related to PSCI, summarizes their mechanisms of action in PSCI, and elucidates the possible crosstalk between different pathways, in order to provide data basis for clinical targeting of regulatory factors in the PCD pathway for the treatment of PSCI.

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  • 收稿日期:2023-07-11
  • 最后修改日期:2023-09-04
  • 录用日期:2024-02-26
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