基于中西医临床病证特点的银屑病性关节炎动物模型分析
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河南中医药大学

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Analysis of animal model of psoriatic arthritis based on the characteristics of Chinese medicine and Western medicine
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1.Henan University of Chinese medicine,Henan Health Aging Industry Engineering Research Center,Zhengzhou Henan 450046;2.China

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    摘要:

    目的:近年来,随着银屑病性关节炎在我国的发病率逐渐升高且无法治愈,已经成为了医学事业上的一大难题。本研究基于中西医临床病证特点,积极探讨银屑病性关节炎的发病病机,总结目前现有的动物模型并进行分析评价。方法:对所检测到符合本题的文献进行整理归纳总结,通过银屑病性关节炎的中西医病因病机研究、中西医的诊断标准以及动物模型的特点及与临床吻合度的分析,给予现有模型吻合度评分。结果:本论述发现人白细胞抗原转基因鼠模型、多重杂交转基因小鼠模型以及甘露聚糖诱导的小鼠模型吻合度评分最高。结论:由于银屑病性关节炎多见于欧洲,目前动物模型的制备方法多由国外传来,中医病症特点制备的动物模型极少,因此,西医诊断的模型吻合度评分整体高于中医诊断的吻合度评分。希望未来可以结合中医的独特诊疗方法,进一步完善银屑病性关节炎的动物模型种类,为中西医结合治疗银屑病性关节炎构建更理想的动物模型提供基础。

    Abstract:

    Purpose: In recent years, with the incidence of psoriatic arthritis gradually increasing and incurable in China, it has become a major problem in the medical career. Therefore, In this study, we actively explored the pathogenesis of psoriatic arthritis based on the characteristics of Chinese and Western medicine clinical evidence, summarized the currently available animal models and analyzed and evaluated them. Methods: Literature detected in line with this topic was collated and summarized, and the existing models were given an agreement score through the study of the etiology and pathogenesis of psoriatic arthritis in Chinese and Western medicine, the diagnostic criteria of Chinese and Western medicine, and the analysis of the characteristics of the animal models and their degree of agreement with the clinic. Results: This thesis found that the human leukocyte antigen transgenic mouse model, the multiple hybridization transgenic mouse model, and the mannan-induced mouse model had the highest fit scores. Conclusion: Since psoriatic arthritis is mostly seen in Europe, the preparation methods of animal models are mostly imported from abroad, and there are very few animal models prepared with the characteristics of Chinese medicine, therefore, the model agreement scores of western diagnosis are higher than those of Chinese medicine diagnosis as a whole. It is hoped that in the future, we can combine the unique diagnosis and treatment methods of Chinese medicine to further improve the types of animal models of psoriatic arthritis, so as to provide a basis for the construction of more ideal animal models for the treatment of psoriatic arthritis by combining traditional Chinese medicine and Western medicine.

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  • 收稿日期:2023-09-14
  • 最后修改日期:2024-03-01
  • 录用日期:2024-03-29
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