河南中医药大学第一附属医院，心脏中心/国家区域（中医）心血管诊疗中心
国家自然科学基金(82274316)；河南省中医药科学研究专项课题(2019JDZX2071，2022JDZX037)。
The First Affiliated Hospital of Henan University of CM, Heart Center/National Regional（Traditional Chinese Medicine）Cardiovascular Diagnosis and Treatment Center
The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)(82274316) ；Henan Province Chinese medicine scientific research special topic(2019JDZX2071，2022JDZX037)
心肌缺血再灌注损伤（myocardial ischemia reperfusion injury，MIRI）已经成为影响心血管疾病患者临床转归的最严重并发症之一，巨噬细胞的免疫炎症反应与MIRI的发生发展密切相关。目前已有多项研究表明，通过影响巨噬细胞的极化和炎症状态、焦亡、浸润等功能，NF-κB信号通路可参与MIRI调节，是MIRI治疗的潜在靶点。因此，本文将对巨噬细胞功能与MIRI调节作用之间的NF-κB信号通路研究进展进行综述。
Myocardial ischemia reperfusion injury（MIRI）has become one of the most serious complications affecting the clinical outcome of patients with cardiovascular diseases. The immune inflammatory response of macrophages is closely related to the occurrence and development of MIRI.Many studies have shown that the NF-κB signaling pathway can participate in MIRI regulation by influencing the polarization and inflammatory state of macrophages, pyrodeath, infiltration and other functions, and is a potential target for MIRI therapy.Therefore, this article will review the research progress of NF-κB signaling pathway between macrophage function and MIRI regulation.
