高原低压低氧环境下牙周炎与中枢神经系统炎症的相关性
作者:
作者单位:

军事认知与脑科学研究所

基金项目:

国家自然科学基金(82072104)


The correlation of periodontitis and central nervous system inflammation in hypobaric hypoxia environment at plateau
Author:
Affiliation:

Institute of Military Cognition and Brain Sciences

Fund Project:

Natural Science Foundation of China(82072104)

  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献 [55]
  • | | | |
  • 文章评论
    摘要:

    近年来,随着在高原和山区活动人群的增多,高海拔暴露变得越来越普遍,许多基础疾病患者受高原低压低氧环境影响,病程进一步加重甚至导致认知障碍的现象频发。牙周炎是一种常见的炎症性疾病,能诱发牙周局部炎症反应,甚至中枢神经系统炎症。在高海拔环境下,机体出现免疫力下降、组织缺氧等反应,这些反应会促进牙周炎的发生发展,甚至有可能增加牙周炎引发中枢神经系统炎症的风险。随着高原医学研究的不断深入,高原低压低氧环境下牙周炎与中枢神经系统炎症之间的关系引发越来越多的关注。本文就牙周炎与中枢神经系统炎症的研究进展进行综述,并对高原低压低氧环境下牙周炎与中枢神经系统炎症之间的相关性进行讨论。

    Abstract:

    In recent years, with the increasing number of people active in the plateau and mountainous areas, high altitude exposure has become increasingly common, and many patients with underlying diseases are affected by the hypobaric hypoxia of the plateau environment, which further aggravates the disease process and even leads to cognitive disorders. Periodontitis is a common inflammatory disease that induces periodontal local inflammatory responses and even causes central nervous system inflammation. At high altitudes, the body suffers from decreased immunity and tissue hypoxia, which can promote the occurrence and development of periodontitis and may even increase the risk of periodontitis leading to central nervous system inflammation. With the deepening of plateau medicine research, the relationship between periodontitis and central nervous system inflammation in the hypobaric hypoxia of plateau environment has attracted more and more attention. This work reviews the research progress of periodontitis and central nervous system inflammation and discusses the correlation between periodontitis and central nervous system inflammation in the hypobaric hypoxia environment at plateau.

    参考文献
    [1] 范明, 朱玲玲. 低氧研究受到关注 [J]. 生理学报, 2019, 71(5): 806-808.
    [2] 向雪梅, 郭鑫, 曾佳容, 等. 高原肺水肿动物模型研究进展 [J]. 中国实验动物学报, 2022, 30(2): 291-298.
    [3] 付鹏宇, 胡扬, 李燕春, 等. 低氧暴露所致大鼠骨骼肌萎缩的蛋白转化调节机制 [J]. 中国实验动物学报, 2019, 27(4): 423-432.
    [4] 张梦雅, 赵名, 江亚群, 等. 慢性高原低氧暴露对小鼠神经行为学的影响 [J]. 中国比较医学杂志, 2023, 33(4): 28-35.
    [5] 刘鹏飞, 胡艳婷, 姜静雯, 等. 通心络胶囊对大鼠低压低氧暴露后炎症反应和脑组织水肿及认知功能的影响 [J]. 中国比较医学杂志, 2021(6), 31: 69-76.
    [6] Zhou Y, Huang X, Zhao T, et al. Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice [J]. Brain Behav Immun, 2017, 64: 266-275.
    [7] Han Y, Ding L, Cheng X, et al. Hypoxia Augments Cerebral Inflammation in a Dextran Sulfate Sodium-Induced Colitis Mouse Model [J]. Front Cell Neurosci, 2020, 14: 611764.
    [8] 蒲东全. 高原驻军官兵口腔保健行为与牙周病、龋病的调查分析 [D]. 第三军医大学, 2010.
    [9] Hu Y, Li H, Zhang J, et al. Periodontitis Induced by P. gingivalis-LPS Is Associated With Neuroinflammation and Learning and Memory Impairment in Sprague-Dawley Rats [J]. Front Neurosci, 2020, 14: 658.
    [10] Johnson A, He JL, Kong F, et al. Surfactin-Loaded ?-Carrageenan Oligosaccharides Entangled Cellulose Nanofibers as a Versatile Vehicle Against Periodontal Pathogens [J]. Int J Nanomedicine, 2020, 15: 4021-4047.
    [11] Teles F, Collman RG, Mominkhan D, et al. Viruses, periodontitis, and comorbidities [J]. Periodontol 2000, 2022, 89(1): 190-206.
    [12] Sun HY, Jiang H, Du MQ, et al. The Prevalence and Associated Factors of Periodontal Disease among 35 to 44-year-old Chinese Adults in the 4th National Oral Health Survey [J]. Chin J Dent Res, 2018, 21(4): 241-247.
    [13] Sun H, Du M, Tai B, et al. Prevalence and associated factors of periodontal conditions among 55- to 74-year-old adults in China: results from the 4th National Oral Health Survey [J]. Clin Oral Investig, 2020, 24(12): 4403-4412.
    [14] Yost S, Duran-Pinedo AE, Teles R, et al. Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis [J]. Genome Med, 2015, 7(1): 27.
    [15] Sanz M, Marco Del Castillo A, Jepsen S, et al. Periodontitis and cardiovascular diseases: Consensus report [J]. J Clin Periodontol, 2020, 47(3): 268-288.
    [16] Kwon T, Lamster IB, Levin L. Current Concepts in the Management of Periodontitis [J]. Int Dent J, 2021, 71(6): 462-476.
    [17] Yan Y, Zhan Y, Wang X, et al. Clinical evaluation of ultrasonic subgingival debridement versus ultrasonic subgingival scaling combined with manual root planing in the treatment of periodontitis: study protocol for a randomized controlled trial [J]. Trials, 2020, 21(1): 113.
    [18] Wang RP, Huang J, Chan K, et al. IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer''s disease [J]. J Neuroinflammation, 2023, 20(1): 71.
    [19] Ilievski V, Zuchowska PK, Green SJ, et al. Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice [J]. PLoS One, 2018, 13(10): e0204941.
    [20] Hao X, Li Z, Li W, et al. Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer''s Mice [J]. Front Immunol, 2022, 13: 816640.
    [21] Pisani F, Pisani V, Arcangeli F, et al. The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer''s Disease Pathology [J]. Int J Environ Res Public Health, 2022, 19(15): 9386.
    [22] Riviere GR, Riviere KH, Smith KS. Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer''s disease [J]. Oral Microbiol Immunol, 2002, 17(2): 113-118.
    [23] Ranjan R, Abhinay A, Mishra M. Can oral microbial infections be a risk factor for neurodegeneration? A review of the literature [J]. Neurol India, 2018, 66(2): 344-351.
    [24] Ma X, Shin YJ, Yoo JW, et al. Extracellular vesicles derived from Porphyromonas gingivalis induce vagus nerve-mediated cognitive impairment [J]. J Adv Res, 2023, 15: S2090-1232(23)00057-7.
    [25] Furutama D, Matsuda S, Yamawaki Y, et al. IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier [J]. Brain Sci, 2020, 10(10): 679.
    [26] Liu Y, Wu Z, Zhang X, et al. Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in reponse to Porphyromonas gingivalis LPS [J]. Mediators Inflamm, 2013, 2013: 407562.
    [27] Qiao C, Zhang Q, Jiang Q, et al. Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson''s disease [J]. J Neuroinflammation, 2018, 15(1): 193.
    [28] Leng S, Xu W, Wu L, et al. NLRP3 Disturbs Treg/Th17 Cell Balance to Aggravate Apical Periodontitis [J]. J Dent Res, 2023, 102: 656-666.
    [29] Suda K, Matsuda K. How Microbes Affect Depression: Underlying Mechanisms via the Gut-Brain Axis and the Modulating Role of Probiotics [J]. Int J Mol Sci, 2022, 23(3): 1172.
    [30] Lin CH, Chen CC, Chiang HL, et al. Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson''s disease [J]. J Neuroinflammation, 2019, 16(1): 129.
    [31] Han Y, Wang B, Gao H, et al. Insight into the Relationship between Oral Microbiota and the Inflammatory Bowel Disease [J]. Microorganisms, 2022, 10(9): 1868.
    [32] Xue L, Zou X, Yang XQ, et al. Chronic periodontitis induces microbiota-gut-brain axis disorders and cognitive impairment in mice [J]. Exp Neurol, 2020, 326: 113176.
    [33] 杜灿, 武洲, 朱爱琴. 高原慢性低氧环境慢性牙周炎与阿尔茨海默病的相关性 [J]. 中华老年医学杂志, 2015, 34(4): 452-454.
    [34] 张纲, 谭颖徽. 高原地区牙周病的系列研究 [J]. 国际口腔医学杂志, 2013, 40(2): 141-143+147.
    [35] 佘建祯, 冯帆, 周兴田, 等. 驻高原与驻平原空军官兵口腔健康现状调查 [J]. 西南军医, 2016, 18(2): 101-103.
    [36] Wu Z, Zhang R, Cheng L, et al. The correlation of altitude with gingival status among adolescents in western China: a cross-sectional study [J]. Environ Geochem Health, 2021, 43(8): 3151-3167.
    [37] 李燕, 张羽涛, 刘倩雯, 等. 高原地区牙周炎患者血清内脂素和瘦素水平的检测分析 [J]. 口腔医学, 2022, 42(1): 58-61.
    [38] Chaparro A, Lozano M, Gaedechens D, et al. Exploring the Expression of Pro-Inflammatory and Hypoxia-Related MicroRNA-20a, MicroRNA-30e, and MicroRNA-93 in Periodontitis and Gingival Mesenchymal Stem Cells under Hypoxia [J]. Int J Mol Sci, 2022, 23(18): 10310.
    [39] 武曦, 黄镜静, 张纲, 等. 模拟高原低氧兔牙周炎模型血清和牙龈组织中sICAM-1及sVCAM-1的含量 [J]. 实用口腔医学杂志, 2012, 28(2): 178-181.
    [40] 武曦, 黄镜静, 张纲, 等. 高原低氧环境对兔牙周炎模型血清和牙龈组织中超氧化物歧化酶活力的影响 [J]. 华西口腔医学杂志, 2012, 30(3): 247-250.
    [41] 张丹丹, 许晓虎. 牙周炎大鼠MMP-2、BGP及炎性细胞因子的表达特点及低氧对于相关因子的影响 [J]. 医学研究杂志, 2018, 47(6): 176-179.
    [42] 周霞, 刘鲁川, 孔耀, 等. 模拟高原条件下牙周炎动物模型龈沟液中C-反应蛋白的变化 [J]. 第三军医大学学报, 2010, 32(2): 107-110.
    [43] 孔耀, 刘鲁川, 周霞, 等. 模拟高原缺氧对慢性牙周炎大鼠血清中MMP-2表达的影响 [J]. 第三军医大学学报, 2010, 32(4): 324-326.
    [44] 孔耀, 刘鲁川, 周霞, 等. 模拟高原缺氧对慢性牙周炎大鼠血清中MMP-3含量变化的影响[J]. 牙体牙髓牙周病学杂志, 2009, 19(12): 677-680+725.
    [45] 黄镜静, 武曦, 张纲, 等. 模拟高原低氧环境对牙龈卟啉单胞菌的影响 [J]. 解放军医学杂志, 2012, 37(4): 375-378.
    [46] 李淼, 张文瑾, 王思凡, 等. 甘肃省高原环境中人群牙周菌群研究 [J]. 兰州大学学报(医学版), 2022, 48(10): 52-56.
    [47] How KY, Song KP, Chan KG. Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line [J]. Front Microbiol, 2016, 7: 53.
    [48] Li C, Li X, Liu J, et al. Investigation of the differences between the Tibetan and Han populations in the hemoglobin-oxygen affinity of red blood cells and in the adaptation to high-altitude environments [J]. Hematology, 2018, 23(5): 309-313.
    [49] 张运华,曹桢吾. 4500米高原1000名官兵牙周炎调查分析 [J]. 解放军预防医学杂志, 1995(2): 150-151.
    [50] 萧智利. 低氧诱导HIF1α抑制hPDLCs生物学活性及牙周炎组织中差异表达LncRNA的筛选 [D]. 重庆医科大学, 2020.
    [51] Bassani B, Cucchiara M, Butera A, et al. Neutrophils'' Contribution to Periodontitis and Periodontitis-Associated Cardiovascular Diseases [J]. Int J Mol Sci, 2023, 24(20): 15370.
    [52] 李婧. 高原地理环境与牙周炎的关系研究进展 [J]. 全科口腔医学电子杂志, 2020, 7(1): 26+36.
    [53] 何雪娇, 蒋俊强, 罗勇军. 高原地理环境与牙周炎的关系研究进展 [J]. 国外医学(医学地理分册), 2015, 36(2): 102-104.
    [54] 赵婷婷. 高原地区藏族中老年牙周炎与认知功能障碍相关性研究 [D]. 青海大学, 2020.
    [55] 王亚杰. 高原地区重度牙周病与轻度认知障碍和阿尔茨海默病的相关性研究 [D]. 青海大学, 2017.
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:225
  • 下载次数: 0
  • HTML阅读次数: 0
  • 引用次数: 0
历史
  • 收稿日期:2023-11-13
  • 最后修改日期:2024-03-11
  • 录用日期:2024-05-13
防诈骗提示!请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭