Objective To introduce and enhance the experimental technique for intraventricular drug delivery via an implantable osmotic pump. Methods Eight-week-old male SD rats were selected, and the requisite equipment and reagents were prepared. Initially, the osmotic pump was assembled and brought to operational status before conducting the implantation surgery. Following anesthesia, the animals underwent skin preparation, and the skull's upper surface was surgically exposed. Utilizing a brain stereotaxic apparatus, a point directly above the ventricle was located, and a small hole was drilled at that location with a high-speed cranial drill. Subsequently, the pump body was implanted subcutaneously in the neck, the needle was inserted into the drilled hole, and secured with dental cement. Once solidified, the needle base was removed, the subcutaneous soft tissue and scalp were sutured in layers, and the animal was returned to its cage for isolated rearing. Results The osmotic pump was successfully implanted subcutaneously in the rat's neck, the needle was securely affixed to the skull, and the catheter interface remained intact. Upon examination of the extracted brain tissue, no significant hematoma was observed around the puncture site or needle tract, and the presence of blue dye in the ventricular and adjacent tissues indicated successful drug delivery to the ventricle. Conclusion The introduction of a brain stereotaxic apparatus for localization assistance, coupled with enhancements to the operational procedure, has rendered the implantation process more accurate and safe, achieving a high success rate in intraventricular drug administration.