Ischemic Stroke(IS)presents a complex pathogenesis,posing numerous challenges in treatment and rehabilitation.Acupuncture, as a traditional Chinese medicine treatment, has garnered widespread attention for its effectiveness in treating IS, particularly in regulating ferroptosis. Ferroptosis is a type of cell death dependent on iron and lipid peroxidation, closely linked to neurological impairment following IS. This article reviews the primary mechanisms of ferroptosis post-IS, emphasizing the interconnections between iron metabolism, lipid peroxidation, mitochondrial damage, and ferroptosis. It further explores the regulatory mechanisms of acupuncture on ferroptosis after IS, including its roles in enhancing mitochondrial function, modulating iron metabolism, alleviating oxidative stress, suppressing inflammatory responses, and influencing various ferroptosis signaling pathways. This aims to provide more scientific evidence and theoretical support for comprehensive therapeutic strategies for IS.