Laboratory animals have played an important role in maintaining human health. Advocating ethics and welfare of laboratory animals is a dual manifestation of technological progress and human civilization, and establishing ethical review of laboratory animals welfare is an effective guarantee for achieving the welfare of laboratory animals. Although the construction of animal welfare ethics in China has developed rapidly in recent years, there are still many problems that need to be continuously improved at this stage. This article is based on the understanding and recognition of the ethical concepts related to the welfare of laboratory animals. It summarizes and discusses some issues discovered during the ethical review of laboratory animals welfare in medical research, and puts forward personal suggestions for exchange and mutual refrence.