The ERM protein family (ezrin, radixin, and moesin) plays a pivotal role in cell morphology, migration, and signal transduction. Ezrin, a prominent member of this family, is highly involved in these processes. Particularly, the phosphorylation of ezrin is crucial, as it regulates the interaction between ezrin and the actin cytoskeleton. This interaction is a key mediator of cytotoxicity in host cells infected with Helicobacter pylori, significantly impacting cell morphology. This review comprehensively summarizes the multifaceted role of ezrin protein in Helicobacter pylori-induced nodular gastritis. It delves into the relationship between ezrin"s structure, function, phosphorylation, and signaling pathways in the context of nodular gastritis. Moreover, this paper highlights ezrin protein as a potential therapeutic target, offering novel insights for the prevention and treatment of nodular gastritis.