1.包头医学院第二附属医院医学检验科;2.格乐大学国际学院公共卫生系,泰国曼谷
1.Department of Medical Laboratory,the Second Affiliated Hospital of Baotou Medical College;2.Department of Public Health,International College,Krirk University,Bangkok ,Thailand
ERM蛋白家族(包括ezrin，radixin，moesin)在细胞形态、迁移和信号转导中扮演着关键角色。Ezrin是ERM蛋白家族的成员之一,是H. pylori感染宿主所致细胞毒性的重要介质,通过ezrin磷酸化可以调节其与肌动蛋白细胞骨架的相互作用,进而对细胞形态产生显著影响。本文综述了ezrin蛋白在H. pylori感染引发的结节性胃炎中的重要性,探讨了ezrin蛋白的结构及其功能、磷酸化及信号通路与结节性胃炎的关系,为以ezrin蛋白作为潜在的治疗靶点对结节性胃炎的防治提供新思路。
The ERM protein family (ezrin, radixin, and moesin) plays a pivotal role in cell morphology, migration, and signal transduction. Ezrin, a prominent member of this family, is highly involved in these processes. Particularly, the phosphorylation of ezrin is crucial, as it regulates the interaction between ezrin and the actin cytoskeleton. This interaction is a key mediator of cytotoxicity in host cells infected with Helicobacter pylori, significantly impacting cell morphology. This review comprehensively summarizes the multifaceted role of ezrin protein in Helicobacter pylori-induced nodular gastritis. It delves into the relationship between ezrin"s structure, function, phosphorylation, and signaling pathways in the context of nodular gastritis. Moreover, this paper highlights ezrin protein as a potential therapeutic target, offering novel insights for the prevention and treatment of nodular gastritis.
