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LRRC8A/VRAC离子通道抗肿瘤作用的研究进展
作者:
作者单位:

1.甘肃中医药大学基础医学院;2.延安大学医学院;3.空军军医大学实验动物中心

基金项目:

国家自然科学基金(82160871)；甘肃省自然科学基金资助项目(22JR5RA591)；甘肃省中医药管理局项目(GZKZ-2021-10)。


Research progress on anti-tumor effects of LRRC8A/VRAC ion channels
Author:
Affiliation:

1.Basic Medical College of Gansu University of Chinese Medicine;2.Yan'3.'4.an University School of Medicine;5.Laboratory Animal Center of Air Force Military Medical University;6.Basic Medical College of Gansu University of Chinese MedicineBasic Medical College of Gansu University of Chinese Medicine;7.Laboratory Animal Center of Air Force Military Medical UniversitLaboratory Animal Center of Air Force Military Medical University

Fund Project:

(GZKZ-2021-10)Funded by National Natural Science Foundation of China (NO. 82160871); Supported by Natural Science Foundation of Gansu Province (NO. 22JR5RA591); Project of Gansu Provincial Administration of Traditional Chinese Medicine (NO. GZKZ-2021-10)

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    摘要:

    体积调节阴离子通道(Volume-regulated anion channels, VRAC)在脊椎动物细胞和各类型的肿瘤细胞中普遍表达。其由富含亮氨酸重复序列的8A(Leucine-rich repeat containing 8A, LRRC8A)及其四个同源家族成员(LRRC8B-E)组成，其中LRRC8A为必需亚基。已证实LRRC8A/ VRAC通过各种信号途径参与肿瘤细胞的增殖、迁移、侵袭及多药耐药，并调控免疫细胞功能。该离子转运蛋白在杀伤肿瘤细胞及预防肿瘤中显示出良好的应用潜力，可作为肿瘤治疗的新靶点。本文综述了LRRC8A/VRAC参与肿瘤发生发展的最新研究，包括LRRC8A/VRAC的分子结构、功能及其在肿瘤中的调控作用，重点总结了LRRC8A/VRAC在肿瘤诊断和免疫治疗中的应用，以期为探索LRRC8A/VRAC成为肿瘤治疗的新靶点提供借鉴。

    Abstract:

    Volume adjusting anion channel (VRAC) in vertebrate cells and each type of general expression in tumor cells. Leucine-rich repeat containing 8A(LRRC8A) and its four homologous family members (LRRC8B-E), of which LRRC8A is an essential subunit. It has been confirmed that LRRC8A/VRAC is involved in the proliferation, migration, invasion and multi-drug resistance of tumor cells through various signaling pathways. This ion transporter has shown good potential in killing tumor cells and preventing the development of tumor, and can be used as a new target for tumor therapy. Therefore, this paper reviews the latest research on the involvement of LRRC8A/VRAC in tumorigenesis and development, including the molecular structure, function and regulation of LRRC8A/VRAC in tumor and immune cells, with emphasis on the application of LRRC8A/VRAC in tumor diagnosis and immunotherapy, in order to provide reference for exploring LRRC8A/VRAC as a new target of tumor therapy.

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  • 收稿日期:2024-02-01
  • 最后修改日期:2024-05-31
  • 录用日期:2024-10-30
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