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线粒体损伤在炎症性肠病中的研究进展
作者:
作者单位:

广东药科大学，广东省药物生物活性物质重点实验室

基金项目:

2023年广东省自然科学基金-面上项目(2023A1515011931)


Research progress on Mitochondrial Damage in Inflammatory Bowel Disease
Author:
Affiliation:

Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances,Guangdong Pharmaceutical University

Fund Project:

2023 Natural Science Foundation of Guangdong Province - Top Project (2023A1515011931)

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    摘要:

    炎症性肠病（inflammatory bowel disease, IBD）是一种严重危害人类健康的慢性复发性肠道炎症疾病。其发病机制尚不明确，可能涉及遗传、免疫和环境等多种因素。近年来，越来越多的研究表明线粒体损伤与功能异常在IBD的发生发展中发挥着重要作用。本综述对炎症性肠病中线粒体损伤的相关研究进行了全面回顾和梳理，重点探讨线粒体氧化应激损伤、自噬功能障碍、动力学紊乱、呼吸功能缺陷对IBD的影响，尝试寻找其潜在治疗靶点，旨在为IBD的科学防治提供新依据。

    Abstract:

    Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract that poses a significant threat to human health. The pathogenesis of IBD remains unclear and is believed to involve various factors such as genetics, immune dysregulation, and environmental triggers. In recent years, increasing evidence has highlighted the role of mitochondrial damage and dysfunction in the development of IBD. This review provides a comprehensive review and overview of studies related to mitochondrial damage in inflammatory bowel disease, focusing on the effects of mitochondrial oxidative stress damage, autophagy dysfunction, kinetic disturbances, and respiratory defects on IBD. The aim is to identify potential therapeutic targets and provide new insights for the scientific prevention and treatment of IBD.

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  • 收稿日期:2024-02-04
  • 最后修改日期:2024-04-14
  • 录用日期:2024-06-28
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