Inflammatory skin diseases (ISD) are characterized by persistent inflammatory infiltration and lingering and intractable skin lesions. At present, corticosteroids are the main drugs used in the treatment of ISD. However, due to the characteristics of recurrent and intractable ISD, long-term use of these hormone drugs may cause serious side effects to patients. In recent years, more and more studies have confirmed that bee venom (BV) has significant anti-inflammatory, anti-apoptosis, anti-fibrosis, antibacterial and other effects, so as to effectively treat ISD. In this paper, the main active components of BV are reviewed and its anti-inflammatory mechanism, and the latest status of BV in acne, atopic dermatitis, psoriasis, urticaria and systemic lupus erythematosus is discussed, which provides reference for the basic research and clinical treatment of ISD.