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NLRP3-细胞焦亡在实验性脓毒症肺损伤中的作用
作者:
作者单位:

河北北方学院基础医学院 微循环研究所

基金项目:

国家自然科学基金(82270524)


Role of NLRP3-pyroptosis in experimental sepsis-induced lung injury
Author:
Affiliation:

Basic Medical College Institute of Microcirculation,Hebei North University,Zhangjiakou

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    摘要:

    NOD样受体热蛋白结构域相关蛋白3（NLRP3）介导的肺实质细胞与免疫细胞焦亡在脓毒症急性肺损伤（ALI）的发生机制中发挥关键作用，且NF-?B、JAK2/STAT3、MAPK等信号通路参与了NLRP3介导的细胞焦亡。靶向NLRP3-细胞焦亡及其相关信号通路，Physalin B 、五味子素、黄芩苷、4-羟基壬烯酸、GYY4137、促红细胞生成素等药物干预、针刺足三里、肺俞穴等物理疗法，以及麦角内酯等NLRP3特异性抑制剂，均发挥了良好的抗脓毒症ALI作用。本文综述NLRP3-细胞焦亡在实验性脓毒症ALI中的作用与机制，以及靶向NLRP3-细胞焦亡防治脓毒症ALI的实验研究进展，期望以NLRP3-细胞焦亡为切入点，为形成脓毒症ALI的防治新策略提供思考。

    Abstract:

    Nod-like receptor pyrin domain-associated protein 3 (NLRP3) -mediated pyroptosis of pulmonary parenchymal and immune cells plays a key role in the pathogenesis of acute lung injury (ALI) during sepsis, and NF-?B, JAK2/STAT3, MAPK signaling pathways are involved in NLRP3-mediated pyroptosis. Targeting NLRP3-pyroptosis and its related signaling pathway, the pharmacological intervention of Physalin B, Schisandrin, 4-hydroxynonenal, Baicalin, GYY4137, and Erythropoietin, the physiatrics of acupuncture at Zusanli and Feishu, and the NLRP3 specific inhibitors such as Ergolide, play a good anti-septic effect on ALI. This article reviews the role and mechanism of NLRP3-pyroptosis in sepsis-induced ALI, as well as the experimental progress of targeting NLRP3-pyroptosis in the prevention and treatment of sepsis-induced ALI, hoping to take NLRP3-pyroptosis as the entry point to provide thinking for the formation of a new prevention and treatment strategy for sepsis-induced ALI.

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  • 收稿日期:2024-02-28
  • 最后修改日期:2024-05-07
  • 录用日期:2024-08-26
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