Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, with an extremely high mortality rate. It is the main risk factor for acute lung injury (ALI). However, the pathophysiology and pathogenesis of sepsis-associated ALI are not fully understood, and effective drugs are extremely limited. Therefore, the urgent task is to explore the pathogenesis of sepsis associated ALI and attempt to discover effective intervention measures to improve the prognosis of sepsis associated ALI patients. In recent years, ferroptosis has been considered closely related to the pathological and physiological processes of sepsis associated ALI, and inhibiting related cell ferroptosis can effectively slow down the occurrence and development of the disease. In this paper, the therapeutic strategies targeting ferroptosis of related cells were reviewed, in order to provide reference for the research on ferroptosis of sepsis associated ALI and provide a new perspective for the treatment of sepsis associated ALI.