基于中西医临床病证特点的动脉粥样硬化动物模型分析
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湖南中医药大学

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国家自然科学基金(81673722);湖南省科技创新计划资助(2021RC4064);湖南省科技厅重点项目(2022SK2011);湖南省教育厅重点项目(20A379);湖南省自然科学(2022JJ40314);湖南省教育厅项目(22B0387);湖南省大学生创新创业训练计划项目(S202210541021);湖南中医药大学重点培育学科基础医学学科(202302)。


Animal Model Analysis of Atherosclerosis Based on Clinical Symptoms in Traditional Chinese Medicine and Western Medicine
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Hunan University of Chinese Medicine

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    摘要:

    目的 对常见动脉粥样硬化(AS)动物模型与中西医临床病证特点进行吻合度分析与评分,为研究AS疾病选择的动物模型提供参考。方法 对常见AS动物模型的品种、造模方法、原理、特点进行总结,并根据AS中西医临床诊断标准对15种常见模型进行吻合度分析。结果 现有AS动物模型常用的制备方法有高脂喂养型、机械损伤联合高脂喂养型、基因工程联合高脂喂养型、化学诱导结合高脂喂养型以及病证结合模型。其中,中西医临床吻合度相对较高的是球囊损伤联合高脂喂养型、ApoE-/-联合高脂喂养型以及病证结合中的痰瘀互结型。结论 现有的AS动物模型大多以西医造模方法为主,评价标准亦以西医诊断指标为主,缺少中西医病证结合的特点,很难揭示中医整体观念、辨证论治的核心。因此,构建准确、高吻合度的中西医病证结合动物模型将是深入研究AS机制和防治的重点。

    Abstract:

    Objectives Based on the clinical characteristics of atherosclerosis in? traditional Chinese medicine (TCM) and Western medicine, this paper analyzes the common animal models of atherosclerosis(AS), and the coincidence of the models with clinical characteristics was scored, in the hope of providing new ideas and reference for studying animal models of AS. Methods This paper reviewed the varieties, modeling methods, modeling principles and characteristics of common animal models of AS. Moreover, according to the clinical diagnostic criteria and symptom characteristics, the similarity of the common animal models was analyzed. Results High-fat feeding type, mechanical injury combined with high-fat feeding type, genetic engineering combined with high-fat feeding type, chemical induction combined with high-fat feeding type and the models of AS combining Chinese clinical syndrome and western disease are widely established in animal models of AS. Comparative analysis result showed that balloon injury combined with high fat feeding type, ApoE receptor knockout mouse combined with high-fat diet type and phlegm and blood stasis type in models of disease and symptom combination showed a comparatively high level of clinical agreement between Chinese and western medicine. Conclusions Presently, most of the animal models of AS had the high degree of coincidence with western medicine, evaluation criterion is dominated by the western medicine as well, which lack of the combination between disease and syndrome, so as to hinder development of concept of Wholism and treatment by differentiation of syndromes in TCM. Therefore, establishing the exact and high coincidence degree animal model, which combines the disease and its TCM symptoms, is the top priority of studying the prevention and treatment of atherosclerosis.

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  • 收稿日期:2024-03-23
  • 最后修改日期:2024-04-30
  • 录用日期:2024-06-11
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