1.山东中医药大学 中医学院;2.山东中医药大学 第一临床医学院;3.济南市疾病预防与控制中心
1.Shandong University of Traditional Chinese MedicineTCM,institute of traditional Chinese medicine;2.Shandong University of Traditional Chinese Medicine,First Clinical Medical College;3.Blood insurance center
抑郁症作为常见的心境障碍,发病机制复杂,近年来随着人们生活节奏的加快,患病率逐年攀升,引起人们的广泛关注。外界应激和炎症共同损害血管和脑区功能,诱发免疫失调,引起小胶质细胞活化和促炎性细胞因子及其受体表达增加,炎症反应持续发生,影响神经递质系统的正常代谢和分子通路的正常运行,导致脑细胞和神经异变,进一步形成的免疫-炎症-神经循环路径成为抑郁症发生发展的重要机制。大量研究表明中医药治疗可以通过恢复神经免疫炎症稳态改善抑郁症状,本文从神经免疫炎症角度出发,阐述其与抑郁症及其发病机制的密切联系,并对多种中医疗法通过调节神经免疫炎症改善和治疗抑郁症的作用进行综述,以期为抑郁症的精准治疗以及中医药免疫靶向药物研发提供新视角。
As a common mood disorder, depression has a complex pathogenesis. In recent years, with the accelerated pace of people’s lives, the prevalence rate has increased year by year, attracting people extensive attention. External stress and inflammation jointly damage blood vessel and brain functions, induce immune disorders, cause microglia activation and increase the expression of pro-inflammatory cytokines and their receptors, inflammatory reaction continues to occur, which affects the normal metabolism and metabolism of the neurotransmitter system. Abnormal functioning of molecular pathways leads to mutations in brain cells and nerves, and the further formation of the immune-inflammation-neuron cycle path becomes an important mechanism in the occurrence and development of depression. a large number of studies have shown that Traditional Chinese medicine treatment can improve depression symptoms by restoring neuroimmune inflammation homeostasis. From the perspective of neuroimmune inflammation, this article explains its close connection with depression and its pathogenesis, and reviews the role of various traditional Chinese medicine antidepressant therapies in improving and treating depression by participating in the regulation of neuroimmune inflammation to provide a new angle of view for the precise treatment of depression and the development of immune-targeted drugs.
