Objective To classify and analyze the existing animal models of hepatic encephalopathy based on the characteristics of Chinese and Western medicine clinical conditions, with a view to providing ideas for improving and perfecting the existing animal models of hepatic encephalopathy, so as to prepare animal models of hepatic encephalopathy that better meet the characteristics of the clinical conditions of Chinese and Western medicine combined with the conditions of hepatic encephalopathy. Methods In China Knowledge Network and Wanfang database, the Keywords "hepatic encephalopathy", "hepatic coma", "animal", "animal model" were used as Keywords, and in Pubmed database, "hepatic encephalopathy", "hepatic coma", " animal model", "animal" as the Keywords to search, collate effective literature with specific animal model preparation methods, collate and classify according to different modeling factors and methods, summarize the modeling methods and characteristics, and assess the clinical match of the animal model based on the characteristics of clinical diseases of hepatic encephalopathy in Chinese and western medicine. The clinical match of the animal model was assigned and analyzed according to the clinical symptoms of hepatic encephalopathy in Chinese and western medicine. Results There were 128 valid literature articles with 11 animal models, including 15 different modeling methods, among which, the CCl4 oil solution model had a high degree of agreement, and the highest degree of agreement in Western medicine was the CCl4 oil solution intraperitoneal injection+gavage+ammonium chloride intraperitoneal injection model (92%), and the highest degree of agreement in traditional Chinese medicine was the CCl4 oil solution intraperitoneal injection+ethanol aqueous solution self-drinking model (65%), but there was a lack of Chinese and Western medicine clinical disease characteristics.Conclusion The existing animal models of hepatic encephalopathy are all in accordance with the characteristics of the disease, but generally lack the manifestation of Chinese medicine, and lack of animal models combining the characteristics of Chinese and Western medicine. Combining the clinical characteristics of Chinese and Western medicine in the preparation of animal models is expected to provide a model basis for clinical diagnosis and treatment of hepatic encephalopathy, and point out the direction for the combination of Chinese and Western medicine in the treatment of hepatic encephalopathy.