运动对阿尔茨海默病的改善作用及机制
作者:
作者单位:

1.扬州工业职业技术学院体育部;2.常州纺织服装职业技术学院体育部


The ameliorative effect of exercise on Alzheimer's disease and mechanisms
Author:
Affiliation:

1.Department of Physical Education,Yangzhou Polytechnic Institute,Yangzhou;2.Department of Physical Education,Changzhou Vocational Institute of Textile and Garment,Changzhou,Jiangsu

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    摘要:

    阿尔茨海默病(Alzheimer's disease,AD)的发病机制是当前生命医学领域的研究焦点之一。运动可作为改善神经退行性疾病的重要手段,研究证实,有氧运动、抗阻运动和多模式运动组合均可显著改善AD。分析发现,其发病机制与运动抑制炎症反应,优化星形胶质细胞和小胶质细胞激活状态,促进海马神经发生以及改善血脑屏障功能密切相关。本文通过对不同运动方式在改善AD中的作用及其机制进行综述,并做出展望,以期为AD的运动防治提供理论和实验依据。

    Abstract:

    The pathogenesis of Alzheimer's disease (AD) is one of the key research focuses in the field of life sciences. Exercise serves as an important intervention for ameliorating neurodegenerative diseases., and studies have demonstrated that aerobic exercise, resistance training, and multimodal exercise combinations can significantly improve AD. Analysis reveals that its pathogenesis is closely associated with the regulation of exercise in suppressing inflammatory responses, optimizing the activation states of astrocytes and microglia, promoting hippocampal neurogenesis, and improving blood-brain barrier function.This article reviews the effects and mechanisms of different exercise methods in improving AD and makes prospects, with the aim of providing theoretical and experimental basis for the exercise prevention and treatment of AD.

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  • 收稿日期:2024-04-18
  • 最后修改日期:2025-02-19
  • 录用日期:2025-04-09
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