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PCOS中胰岛素抵抗、高雄激素血症与线粒体氧化应激的关系探讨
作者:
作者单位:

1.河南中医药大学;2.河南中医药大学第一附属医院

基金项目:

] 国家自然科学基金(81973596)； (河南中医药大学博士科研启动(RSBSJJ2019-29);河南中医药大学重点学科建设项目(15102044-2020)； 河南省中医药传承与创新人才工程(仲景工程)中医药青苗人才培养项目(豫卫中医函[2021]16号)


The Relationship Between Insulin Resistance, Hyperandrogenism, and Mitochondrial Oxidative Stress in PCOS
Author:
Affiliation:

1.Henan University of Chinese Medicine;2.First Affiliated Hospital of Henan University of Chinese Medicine

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  • 参考文献 [57]
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    摘要:

    多囊卵巢综合症(Polycystic ovarian syndrome,PCOS)是妇产科常见的生殖内分泌代谢疾病。胰岛素抵抗((insulin resistance, IR)、高雄激素血症(Hyperandrogenemia,HA)是PCOS的两个重要特征,在其发生发展过程中起到重要作用。有研究发现,PCOS患者与线粒体氧化应激存在一定关系,这种氧化应激又受到多种因素的影响,尤其是胰岛素抵抗和高雄激素血症。该文对胰岛素抵抗、高雄激素血症与线粒体氧化应激的关系,以及胰岛素抵抗和高雄激素血症对PCOS患者线粒体氧化应激的影响进行了综述。

    Abstract:

    Polycystic ovarian syndrome (PCOS) stands as a prevalent reproductive endocrine metabolic disorder within obstetrics and gynaecology. Two pivotal features of PCOS are insulin resistance (IR) and hyperandrogenemia (HA), both instrumental in its pathogenesis. There exists a discernible correlation between PCOS patients and mitochondrial oxidative stress, a relationship heavily influenced by various factors, notably insulin resistance and hyperandrogenemia. This article endeavors to elucidate the interplay between insulin resistance, hyperandrogenemia, and mitochondrial oxidative stress, while also exploring the impacts of insulin resistance and hyperandrogenemia on mitochondrial oxidative stress among PCOS patients.

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