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低氧预适应对HT22细胞和小鼠海马突触和突触旁中NR2B及其酪氨酸1336的磷酸化的影响
作者:
作者单位:

1.广东省深圳市龙岗区第三人民医院ICU;2.泰国格勒大学公共卫生学院,曼谷;3.内蒙古低氧适应转化医学重点实验室;4.深圳市龙岗区第三人民医院

基金项目:

] 国家自然科学基金(编号：82060337)；深圳市科技计划计划项目基础研究面上项目(编号：JCYJ20220531092412028)；深圳市龙岗区医疗卫生科技计划项目 (编号：LGKCYLWS2021000033)。


Effects of hypoxic preconditioning on NR2B in mouse hippocampal cell and HT22 cell
Author:
Affiliation:

1.Department of ICU, The Third People'2.'3.s Hospital of Longgang District;4.Department of Public Health, Krirk University, Bangkok;5.Key Laboratory of Hypoxic Translational Medicine of Inner Mongolia,;6.Translational Medicine Center, The Third People'

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    摘要:

    目的： N-甲基-D-天冬氨酸(NMDA)受体亚基2B(NR2B)及其磷酸化参与大脑缺血/低氧神经损伤。低氧预适应(HPC)作为一种内源性保护干预措施,可以保护大脑免受缺血/低氧损伤。本研究拟通过体内和体外实验研究HPC对海马细胞中NR2B及其两个酪氨酸位点(1252和1336)磷酸化的影响,探讨其在HPC神经保护中的作用。

    Abstract:

    objective: N-methyl-D-aspartate (NMDA) receptor subunit 2B (NR2B) and its phosphorylation are involved in cerebral ischemia/hypoxic neural injury. Hypoxic preconditioning (HPC) serves as an endogenous protective intervention to protect the brain from ischemic/hypoxic injury. This study intends to explore the effect of HPC on NR2B and its two tyrosine sites phosphorylation (1252 and 1336) in hippocampal cells through in vivo and in vitro experiments, and explore its role in HPC neuroprotection.

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  • 收稿日期:2024-05-15
  • 最后修改日期:2024-06-17
  • 录用日期:2024-08-02
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