Insomnia, a prevalent clinical condition, not only diminishes patients" quality of life but also has the potential to give rise to further health complications. Traditional Chinese medicine has amassed and passed down knowledge about treating insomnia for thousands of years, resulting[1] in distinct advantages. It utilises syndrome differentiation and therapy to accomplish therapeutic effects by regulating the internal balance of the human body. To get a deeper understanding of how Traditional Chinese Medicine (TCM) treats insomnia, it is crucial to create animal models that exhibit symptoms closely resembling those found in humans with insomnia. This article provides a concise overview of the current disease-syndrome combination models, which may be classified into four categories: liver-depression, liver-depression for fire or liver-depression for spleen deficiency, heart-spleen deficiency, heart-kidney incompatibility, Yin and blood deficiency, This discussion will focus on particular modelling methodologies, assessment indicators, and model performance. The aim is to enhance the understanding of the pathophysiology of this disease in the context of traditional Chinese medicine. Additionally, this discussion aims to provide technical assistance for clinical efficacy evaluation and the creation of novel drugs.