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神经纤毛蛋白-1在动脉粥样硬化中的作用机制研究进展
作者:
作者单位:

1.浙江中医药大学第一临床医学院;2.浙江省中医院心血管内科

基金项目:

国家自然科学基金项目（面上项目，重点项目，重大项目）


Research Progress on the Mechanisms of Neuropilin-1 in Atherosclerosis
Author:
Affiliation:

1.the First Clinical Medical College of Zhejiang Chinese Medicinal University;2.Department of Cardiology，Zhejiang Provincial Hospital of Traditional Chinese Medicine

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    动脉粥样硬化(atherosclerosis, AS)是冠心病的主要病理基础，对其进程的干预对于冠心病的预防和治疗具有重要意义。神经纤毛蛋白-1(neuropilin-1, NRP1)属于neuropilin受体家族，与包括血管内皮生长因子(vascular endothelial growth factor, VEGF)和转化生长因子β(transforming growth factor-β, TGF-β)在内的多种生长因子关系密切。NRP1通过其在血管生成、炎症反应和血管内皮壁面剪切应力感受等过程中发挥的重要作用影响AS进程。因此，深入探索NRP1在AS中的作用机制，开发针对NRP1的靶向治疗策略，将为AS的诊断和治疗提供新的思路。

    Abstract:

    Atherosclerosis(AS), the primary pathological basis of coronary heart disease, is of significant importance in the prevention and treatment of coronary heart disease. Neuropilin-1 (NRP1), a member of the neuropilin receptor family, is closely associated with various growth factors, including vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β). NRP1 influences the progression of atherosclerosis through its crucial roles in angiogenesis, inflammatory responses, and the sensing of shear stress on the vascular endothelium. Therefore, a thorough exploration of the mechanisms underlying NRP1's role in atherosclerosis and the development of NRP1-targeted therapeutic strategies will provide new insights into the diagnosis and treatment of atherosclerosis.

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  • 收稿日期:2024-05-28
  • 最后修改日期:2025-02-20
  • 录用日期:2025-04-09
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