Alzheimer"s disease (AD) is a neurodegenerative disease caused by a variety of risk factors, which is the main cause of dementia in the old people. At present, the pathogenesis of AD has not been studied clearly, and the treatment of AD is very limited. Clinical drugs can only alleviate the symptoms of AD to a certain extent, but can not delay the course of AD. At present, the pathogenesis of AD has not been studied clearly, and the treatment of AD is very limited. Clinical drugs can only alleviate the symptoms of AD to a certain extent, but can not delay the course of AD. A large number of studies have shown that a variety of micronutrients play a positive role in the treatment of AD. Vitamins, trace metal elements, unsaturated fatty acids and polyphenols have many functions such as anti-inflammation, anti-oxidation and protection of mitochondria. Micronutrients can effectively reduce Aβ protein plaque deposition and Tau protein hyperphosphorylation to improve brain energy metabolism, thereby achieving the prevention and treatment of AD. The purpose of this article is to explore the mechanism of micronutrients in the treatment of AD, and to review its application and effect in the treatment of AD, and to provide theoretical basis and new strategies for micronutrient intervention in the treatment of AD.