【】 Ischemic stroke (IS) is a neurological disease that damages brain tissue from insufficient blood supply to the brain due to blockage or stenosis of the brain vessels. In recent years, there has been increasing evidence that the Wnt/β-catenin signaling pathway plays an important role in the pathophysiological response to the occurrence and development of IS. Programmed cell death includes many forms such as apoptosis, necrotic apoptosis, pyrodeath, autophagy, panapoptosis and iron death. In this review, we will elucidate the characteristics of these different cell death modes and their cross-talk relationships with each other, and systematically outline the role of Wnt/β-catenin signaling pathways in the intervention of different cell death modes in IS, aiming to provide reference for future clinical and basic research.