Parkinson"s disease (PD) is a neurodegenerative disease commonly found in middle-aged and elderly people. A type of disease characterized by static tremors, bradykinesia, muscle rigidity, and postural balance disorders in clinical practice. Berberine (BBR) is a natural quinoline alkaloid. In recent years, studies have found that berberine has hypoglycemic, lipid-lowering, antioxidant, and anti-inflammatory effects, and can effectively improve the misfolding and aggregation of alpha synuclein. Its mechanism of action may include reducing inflammation, alleviating oxidative stress, improving mitochondrial autophagy, regulating intestinal microbiota, and clearing function. This article systematically reviews the mechanism of action and research status of berberine in the neuroprotective field of Parkinson"s disease, providing some reference for the future clinical application and treatment of berberine in Parkinson"s disease.