1.中国中医科学院医学实验中心;2.北京大学第一医院耳鼻咽喉头颈外科;3.清华大学附属北京清华长庚医院耳鼻咽喉头颈外科;4.山西中医药大学基础医学院
中药复杂作用解析协同创新团队项目XTCX2023001
1.Center for Medical Experiments,China Academy of Chinese Medical Sciences;2.Peking University First Hospital;3.Beijing Changgeng Hospital Affiliated to Tsinghua University;4.School of Basic Medicine,Shanxi University of Traditional Chinese Medicine
Analysis of complex effects of traditional Chinese medicine collaborative innovation team projectXTCX2023001
［］:咽喉反流性疾病(LPRD)是一种在上呼吸道和上消化道共同发生的疾病。发病机制复杂,尚缺乏有效治疗办法,合理的动物模型和标准的评价方法对探究其发病机制和开发新型治疗药物尤为重要。新西兰兔是本病常用的造模动物,球囊扩张术是常用的造模方法。本病较为标准的评价方法包括症状观察评价、影像学评价及PH监测等。通过查阅国内外文献,对咽喉反流的动物模型和评价指标进行了详尽地综述,以期对今后的研究提供参考。
Throat reflux disease (LPRD) is a disease that occurs in both the upper respiratory tract and the upper digestive tract. The pathogenesis is complex and there is still a lack of effective treatment. Reasonable animal models and standard evaluation methods are particularly important to explore the pathogenesis and develop new therapeutic drugs. New Zealand rabbits are commonly used to model the disease, and balloon dilatation is commonly used to model the disease. The standard evaluation methods of this disease include symptom observation and evaluation, imaging evaluation and PH monitoring. The animal models and evaluation indexes of pharyngeal reflux were reviewed in detail by referring to domestic and foreign literatures, in order to provide reference for future research.
