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铁死亡介导急性白血病的机制研究进展
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江西中医药大学


Research progress on the mechanism of acute leukemia mediated by ferroptosis
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Jiangxi University of Traditional Chinese Medicine

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    摘要:

    铁死亡主要与铁、脂质和氨基酸等代谢途径有关,这些途径有助于活性氧的产生,使线粒体损伤,致使细胞死亡。近年来,铁死亡在肿瘤发展过程中被认为是一种关键的调控机制,在急性白血病中也不例外。该综述旨在对铁死亡及其在急性白血病发生发展中的作用机制进行综述,探讨铁死亡是如何影响急性白血病细胞的增殖,为未来针对白血病的研究以及治疗提供新的思路。

    Abstract:

    Ferroptosis is mainly related to iron, lipid and amino acid metabolic pathways, which contribute to the production of reactive oxygen species, mitochondrial damage and finally cell death. Ferroptosis primarily involves iron, lipid, and amino acid-related metabolic pathways that contribute to the production of lipid reactive oxygen species. In recent years, ferroptosis has been recognized as a key regulatory mechanism during tumor development, and it is no exception in acute leukemia. The purpose of this article is to review ferroptosis and its mechanism in the development of acute leukemia, and to explore how ferroptosis affects acute leukemia,which provides new ideas for future research and treatment of leukemia.

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  • 收稿日期:2024-08-27
  • 最后修改日期:2025-02-22
  • 录用日期:2025-04-09
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