花粉诱导的过敏性鼻炎动物模型研究进展
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作者单位:

1.天津中医药大学;2.内蒙古医科大学

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基金项目:

国家自然科学基金(82105045)


Progress in the animal model of pollen-induced allergic rhinitis
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Affiliation:

1.Tianjin University of Traditional Chinese Medicine;2.Inner Mongolia Medical University

Fund Project:

National Natural Science Foundation of China (82105045)

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    摘要:

    摘要:花粉变应原诱导的过敏性鼻炎(allergic rhinitis,AR)又称季节性过敏性鼻炎(seasonal allergic rhinitis,SAR),通常发生在风媒植物的花粉散播期。在过去的30年里,SAR的发病率已增加了超过一倍。SAR的病因复杂,涉及多种因素,包括花粉变应原的种类、环境气候因素、遗传因素、人体免疫状态等。动物模型是理解AR发病机制和推动有效防治策略发展的重要工具,本文通过总结近年来国内外关于花粉致敏AR动物试验的文献,系统阐述了影响模型效果的因素,包括动物品系、致敏材料即花粉抗原的制作及存在问题、佐剂的使用及存在问题、造模的步骤、效果评价。这些内容旨在为建立合适的花粉致敏AR动物模型及其相关的基础研究和应用研究提供参考和支持。

    Abstract:

    【Abstract】Pollen allergen-induced allergic rhinitis (AR), also known as seasonal allergic rhinitis (SAR), typically manifests during the pollen dissemination period of anemophilous plants. Over the past three decades, the prevalence of SAR has more than doubled. The etiology of SAR is multifaceted, encompassing various elements such as pollen allergens, environmental and climatic conditions, genetic predispositions, and the immunological status of individuals.Animal models serve as a critical tool in elucidating the mechanisms underlying AR and in advancing the development of efficacious preventive and therapeutic strategies. This review synthesizes the pertinent literature on pollen-sensitized AR animal experiments conducted both domestically and internationally over recent years. It systematically delineates the factors influencing the efficacy of these models, including the selection of animal strains, the production and associated challenges of sensitizing agents, specifically pollen antigens, the utilization and limitations of adjuvants, the procedural steps involved in model creation, and the methodologies for evaluating model effectiveness.The insights provided herein are intended to offer guidance and support for the development of appropriate animal models of pollen-induced AR, thereby facilitating both fundamental and applied research in this area.

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  • 收稿日期:2024-09-02
  • 最后修改日期:2024-09-19
  • 录用日期:2024-12-27
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