表观遗传学在谵妄疾病中的作用和机制研究进展

表观遗传学在谵妄疾病中的作用和机制研究进展
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                        许欣宜许欣宜
天津中医药大学第一附属医院，国家中医针灸临床医学研究中心
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作者单位:天津中医药大学第一附属医院，国家中医针灸临床医学研究中心
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基金项目:国家自然科学基金(82405123)；天津市教委科研计划项目(2022ZD046)；天津中医药大学研究生科研创新项目(YJSKC-20232007)

Research Progress on the Role and Mechanisms of Epigenetics in Delirium Diseases

Author:

xuxinyi
xuxinyi
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
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Affiliation:

National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Fund Project:

National Natural Science Foundation of China(82405123)；Scientific Research Project of the Tianjin Education Commission (2022ZD046)；TUTCM Graduate Research Innovation Project (YJSKC-20232007）

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摘要:

谵妄发病率高,易导致患者不良预后,目前发病机制尚不完全明确,临床上主要采取抗精神病药物进行干预,尚无药物能够明确改善谵妄患者远期健康相关生活质量。对非编码核糖核酸、DNA甲基化、组蛋白乙酰化等表观遗传修饰与谵妄发生发展相关研究进行综述,以期为谵妄的早期识别与诊断、治疗及预后提供临床决策,为相关靶向药物的研发提供借鉴。

关键词:谵妄;表观遗传学;非编码核糖核酸;DNA甲基化;组蛋白乙酰化

Abstract:

Delirium has a high incidence and is prone to lead to poor prognosis of patients. The pathogenesis is still not completely clear, and antipsychotic drugs are mainly used to intervene in clinical practice, and there is no drug that can definitively improve the long-term health-related quality of life of patients with delirium. In this study, we review the research on the association between epigenetic modifications such as non-coding RNA, DNA methylation, histone acetylation and the development of delirium, with the aim of providing clinical decisions on the early identification and diagnosis of delirium, its treatment and prognosis, and the development of relevant targeted drugs.

Key words:Delirium; Epigenetics; Non-coding RNA; DNA Methylation; Histone Acetylation

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收稿日期:2024-11-07
最后修改日期:2024-12-11
录用日期:2025-02-18
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